Feb 22, 2023

From Runner's High to Endorphins and Mood Enhancement

Endorphins and mood Enhancement

Keeping your mind and emotions in a healthy place is essential when you are overwhelmed with anxiety and stress.

From Runner's High to Endorphins and Mood Enhancement

On a Sunday morning last month, I went on my regular morning walk and encountered Bhoomi, a friend of mine who is a dedicated runner and frequently participates in major marathons in Kerala. I noticed that she seemed to be in a joyful and exuberant mood, beaming with energy and excitement. I asked about her run that day and was taken aback by the incredible experience she shared.


Me: Hey Bhoomi, how was your run today?

Bhoomi: Hi there! it was wild. Something crazy happened to me while I was running.

Me: Really? What happened?

Bhoomi: It was like nothing I've ever felt before. I felt like I was on top of the world. It was like I was flying. I was laughing, humming and felt so good.

Me: Wow! What was that about?

Bhoomi: I think it is the rare occurrence of “runner's high". When runners run hard, they get this feeling. I heard that, it is cause by endorphins, the happy chemicals in our brain.


This has sparked my interest in the connection between physical activity and the mind in a deeper level. After conducting a week-long research, I have learned more about the unique phenomenon of "runner's high" and the various scientific explanations behind it. The intense release of endorphins during high-intensity exercise is just one of the many changes that occur in our brain chemistry. This newfound knowledge has provided me with a deeper understanding of what occurs during intense physical activity.

The term "runner's high" refers to the feeling of ecstasy that runners often encounter during or post an intense workout. It is believed to stem from the secretion of neurotransmitters such as endorphins, dopamine, and norepinephrine, which regulate mood, motivation, and pain sensation. These neurotransmitters, when released, elevate mood, reduce anxiety, stress, and depression, and foster a sense of joy and well-being.

The runner's high concept underscores the significance of exercise for mental health and the positive impact it has on mood. The release of endorphins and neurotransmitters during physical activity has been proven to enhance mental well-being, thereby diminishing stress, anxiety, depression and fostering euphoria and happiness.

How exercise affects neurotransmitter production and release

Exercise - a cornerstone of physical health - can have a profound effect on our mental state. Defined as any movement that demands energy expenditure, it encompasses structured regimens like weightlifting and running, and leisure activities such as gardening or dancing. Mental health, on the other hand, encompasses our emotional, psychological, and social well-being, determining our outlook on life, our ability to manage stress and form meaningful relationships.

Though distinct in essence, exercise and mental health are intricately linked. Evidence supports the notion that exercise positively impacts mental health, boosting mood, reducing stress and anxiety, and improving cognitive function. It can also serve as therapy, offering an outlet for negative emotions and fostering a sense of control in individuals.

Given the vital nature of both exercise and mental health, it is crucial to understand their interplay. By delving into the mechanisms by which exercise influences mental health, and exploring the various types of exercise that are most beneficial for our well-being, we can gain a deeper understanding of how to promote optimal health and happiness

The Interplay of Endorphins and Neurotransmitters with our Emotional Landscape

Our emotional states are intricately woven with the delicate balance of neurotransmitters coursing through our bodies, chief among them, the all-powerful endorphins. Dubbed the "feel-good" chemical, endorphins are the body's own natural painkillers, inducing sensations of pleasure while simultaneously alleviating pain. These wonder chemicals forge bonds with specific receptors in the brain, blocking the transmission of pain signals and thereby inciting euphoria.

But endorphins are not the sole purveyors of our mood, anxiety, and stress levels. Other neurotransmitters, such as dopamine, serotonin, and norepinephrine, also hold immense sway over our mental well-being. Dopamine, the motivator and regulator of our reward system, serotonin, the "feel-good" hormone regulating mood and anxiety, and norepinephrine, overseeing attention, focus, and arousal, all contribute to our emotional state. These neurotransmitters are produced and disseminated by neurons in the brain, transmitting signals between nerve cells.

Exercise has been found to be a potent catalyst for the production and release of these neurotransmitters. Regular physical activity has been linked to elevated levels of endorphins, dopamine, serotonin, and norepinephrine. The rush of endorphins during exercise acts as a potent painkiller, while the increase in dopamine, serotonin, and norepinephrine leads to improved mood and reduced stress levels. Exercise also promotes the growth and function of neurons in the brain, thereby enhancing cognitive function and overall mental well-being.

The Brain's Finely Tuned Symphony of Neurotransmitters and Mental Health

The human brain is a labyrinthine web of neurons, each communicating with the other through the delicate symphony of neurotransmitters. These chemical messengers play a critical role in regulating the ebb and flow of our moods, our levels of anxiety and stress, and ultimately, our overall well-being.

Endorphins, famously referred to as the "feel-good" hormones, are the body's natural painkillers and mood elevators. Triggered by stimuli like exercise, laughter, and social connection, endorphins work by binding to specific receptors in the brain, thereby reducing pain and inducing feelings of euphoria. On the other hand, dopamine, a neurotransmitter that motivates and rewards, regulates the brain's reward system. Meanwhile, serotonin, the neurotransmitter that manages mood and anxiety, keeps us balanced and serene. And norepinephrine, which regulates attention, focus, and arousal, helps keep us alert and focused.

However, imbalances in neurotransmitter levels can lead to a host of mental health issues, including depression, anxiety, and stress. Low levels of serotonin, for instance, have been linked to depression, while a dip in dopamine levels can result in reduced motivation and an impaired ability to experience pleasure. When it comes to anxiety, imbalances in neurotransmitter levels, particularly a decrease in norepinephrine, can play a crucial role. And when it comes to stress, imbalances in neurotransmitter levels, particularly low levels of endorphins and dopamine, can lead to increased stress levels.

The Vital Nexus: Exercise and Mental Health Unveiled by Science

Science continues to unravel the intricate connection between exercise and mental health, uncovering a vast and growing body of research that sheds light on the impact of physical activity on our mental well-being. As it turns out, exercise can be an effective ally in the fight against a host of mental health conditions, including depression, anxiety, and stress.

So, what is the secret behind this connection? It all comes down to changes in neurotransmitter levels, neurogenesis, and neuronal function. Exercise has been proven to boost the levels of neurotransmitters such as endorphins, dopamine, serotonin, and norepinephrine, all of which play a crucial role in regulating mood and anxiety. Additionally, exercise stimulates neurogenesis, the production of new brain cells, resulting in improved cognitive function and heightened mental well-being.

Exercise also proves to be a formidable opponent against anxiety and stress. Regular physical activity has been shown to reduce cortisol levels, the hormone responsible for stress, and increase endorphins, thus reducing anxiety and stress levels. Furthermore, exercise has a positive effect on the brain's stress response system, reducing the intensity and frequency of stress responses, and promoting feelings of calm and relaxation.


Prasad Amore
Prasad Amore

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